The Perception of Globally Coherent Motion

How do human observers perceive a coherent pattern of motion from a disparate set of local motion measures? Our research has examined how ambiguous motion signals along straight contours are spatially integrated to obtain a globally coherent perception of motion. Observers viewed displays containing a large number of apertures, with each aperture containing one or more contours whose orientations and velocities could be independently specified. The total pattern of the contour trajectories across the individual apertures was manipulated to produce globally coherent motions, such as rotations, expansions, or translations. For displays containing only straight contours extending to the circumferences of the apertures, observers' reports of global motion direction were biased whenever the sampling of contour orientations was asymmetric relative to the direction of motion. Performance was improved by the presence of identifiable features, such as line ends or crossings, whose trajectories could be tracked over time. The reports of our observers were consistent with a pooling process involving a vector average of measures of the component of velocity normal to contour orientation, rather than with the predictions of the intersection-of-constraints analysis in velocity space.Air Force Office of Scientific Research (90-0175, 89-0016); National Science Foundation, Office of Naval Research, Air Force Office of Scientific Research (BNS-8908426

Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes

Background Despite the number of medications for type 2 diabetes, many people with the condition do not achieve good glycaemic control. Some existing glucose-lowering agents have adverse effects such as weight gain or hypoglycaemia. Type 2 diabetes tends to be a progressive disease, and most patients require treatment with combinations of glucose-lowering agents. The sodium glucose co-transporter 2 (SGLT2) receptor inhibitors are a new class of glucose-lowering agents. Objective To assess the clinical effectiveness and safety of the SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. Data sources MEDLINE, Embase, Cochrane Library (all sections); Science Citation Index; trial registries; conference abstracts; drug regulatory authorities; bibliographies of retrieved papers. Inclusion criteria Randomised controlled trials of SGLT2 receptor inhibitors compared with placebo or active comparator in type 2 diabetes in dual or combination therapy. Methods Systematic review. Quality assessment used the Cochrane risk of bias score. Results Seven trials, published in full, assessed dapagliflozin and one assessed canagliflozin. Trial quality appeared good. Dapagliflozin 10 mg reduced HbA1c by −0.54% (weighted mean differences (WMD), 95% CI −0.67 to −0.40) compared to placebo, but there was no difference compared to glipizide. Canagliflozin reduced HbA1c slightly more than sitagliptin (up to −0.21% vs sitagliptin). Both dapagliflozin and canagliflozin led to weight loss (dapagliflozin WMD −1.81 kg (95% CI −2.04 to −1.57), canagliflozin up to −2.3 kg compared to placebo). Limitations Long-term trial extensions suggested that effects were maintained over time. Data on canagliflozin are currently available from only one paper. Costs of the drugs are not known so cost-effectiveness cannot be assessed. More data on safety are needed, with the Food and Drug Administration having concerns about breast and bladder cancers. Conclusions Dapagliflozin appears effective in reducing HbA1c and weight in type 2 diabetes, although more safety data are needed

Assessment of alternative strategies for sludge disposal into deep ocean basins off Southern California

The general framework of engineering alternatives for regional ocean sludge disposal is well described in a report by Raksit, and will not be repeated here. The various ocean disposal alternatives are less costly than all land-disposal and incineration/pyrolysis systems studied. Even though ocean sludge disposal is currently contrary to both state and federal regulations, it is hoped that this study will advance our scientific and engineering knowledge of the behavior and effects of sludge discharge in deep water, in case the regulatory policy is reexamined in the future. With this report we hope we have demonstrated the potential and difficulties of some new modeling techniques for predicting the effects of sludge discharge in the ocean. In the future. we believe it will be possible to formulate policy of ocean sludge discharges with much better case-by-case predictions of impacts for comparison with other alternatives (such as land disposal). not only for the Los Angeles/Orange County areas, but for all coastal urban areas

Research report: 1983-1985

The Environmental Quality Laboratory at Caltech is a center for research on large scale systems problems of natural resources and environmental quality. The principal areas of investigation at EQL are: 1. Air quality management. 2. Water resources and water quality management. 3. Control of hazardous substances in the environment. 4. Energy policy, including regulation, conservation and energy-environment trade-offs. 5. Resources policy (other than energy); residuals management. EQL research includes technical assessments, computer modeling, studies of environmental control options, policy analyses, and research on important components of the large scale systems. Field work is also undertaken at EQL, some in collaboration with other organizations, to provide critical data needed for evaluation of systems concepts and models. EQL's objectives are as follows: 1. To do systematic studies of environmental and resources problems. The results of these studies, including the clarification of policy alternatives. are communicated to decision-makers in government and industry, to the research community, and to the public. As an organization. EQL refrains from advocating particular policies, but seeks to point out the implications of the various policy alternatives. 2. To contribute to the education and training of people in these areas through involvement of pre-doctoral students, post-doctoral fellows, and visiting faculty members in EQL activities. This educational effort is just as important as the results of the studies themselves, and should make lasting contributions to the nation's ability to solve its environmental and resources problems. The work at EQL goes beyond the usual academic research in that it tries to organize and develop the knowledge necessary to clarify society's alternatives by integrating relevant disciplines. EQL works on solving problems of specific localities when there is a strong element of public interest or educational value, or the concepts and results are applicable to other places. The research of EQL is done under the supervision of faculty members in Environmental Engineering Science, Chemical Engineering, and Social Science. This research report covers the period from October 1983 through September 1985

Colloidal diffusion and hydrodynamic screening near boundaries

The hydrodynamic interactions between colloidal particles in small ensembles are measured at varying distances from a no-slip surface over a range of inter-particle separations. The diffusion tensor for motion parallel to the wall of each ensemble is calculated by analyzing thousands of particle trajectories generated by blinking holographic optical tweezers and by dynamic simulation. The Stokesian Dynamics simulations predict similar particle dynamics. By separating the dynamics into three classes of modes: self, relative and collective diffusion, we observe qualitatively different behavior depending on the relative magnitudes of the distance of the ensemble from the wall and the inter-particle separation. A simple picture of the pair-hydrodynamic interactions is developed, while many-body-hydrodynamic interactions give rise to more complicated behavior. The results demonstrate that the effect of many-body hydrodynamic interactions in the presence of a wall is much richer than the single particle behavior and that the multiple-particle behavior cannot be simply predicted by a superposition of pair interactions

Base Flow Characteristics for Several Four-Clustered Rocket Configurations at Mach Numbers from 2.0 to 3.5

A generalized study of base flow phenomena has been conducted with four 500-pound-thrust JP-4 fuel-liquid-oxygen rocket motors installed in the base of a 12-inch-diameter cylindrical model. Data were obtained over a Mach number and nozzle pressure ratio range of 2.0 to 3.5 and 340 to 600, respectively. Base heat flux, gas temperature, and pressure were highest in the center of the cluster core and decreased in a radial direction. Although a maximum heat flux of 93 Btu per square foot per second was measured within the cluster core, peripheral heat fluxes were low, averaging about 5 Btu per square foot per second for all configurations. Generally base heat flux was found to be independent of Mach number over the range investigated. Base heat flux within the cluster core was decreased by increasing motor spacing, motor extension, a combination of increasing nozzle area ratio and decreasing exit angle and gimbaling the two side engines. Small amounts of nitrogen injected within the cluster core sharply reduced core heat flux

Experimental study of moment sharing in multi-joist timber-concrete composite floors from zero load up to failure

The critical T-sections of multi-joist timber-concrete composite (TCC) floors must be designed at ultimate for support shear force and midspan moment, both of which are influenced by transverse sharing, but to different extents. Prior experimental work has investigated only support reaction sharing and only up to serviceability loads. The present experimental study builds on that status quo by quantifying also moment sharing, via strain gauge layouts at quarter-span and midspan, along with reaction sharing via load cells at the supports of a multi-joist TCC specimen, over the entire load range up to failure. Use of steel mesh connectors bonded into hardwood laminated veneer lumber joists, and near geometric resemblance to a real building TCC floor recently built in London, were novel features of the specimen. The results show that midspan moment and reaction sharing both vary nonlinearly with load, but in distinctly different ways from each other (with up to almost 20% difference observed between them), in the progression between the uncracked, cracked and connection ductility regimes. In this approach reliable assessment of moment sharing depends on the quality of the recorded strains. Accordingly, the strain data were shown to be of high quality by converting these data to internal stress resultants that were then found to satisfy longitudinal equilibrium. It is concluded that this strain gauge layout is useful for future work aimed at building a database of transverse sharing of moments in TCCs

Noise effect on Grover algorithm

The decoherence effect on Grover algorithm has been studied numerically through a noise modelled by a depolarizing channel. Two types of error are introduced characterizing the qubit time evolution and gate application, so the noise is directly related to the quantum network construction. The numerical simulation concludes an exponential damping law for the successive probability of the maxima as time increases. We have obtained an allowed-error law for the algorithm: the error threshold for the allowed noise behaves as Eth(N) ~ 1/N1.1 (N being the size of the data set). As the power of N is almost one, we consider the Grover algorithm as robust to a certain extent against decoherence. This law also provides an absolute threshold: if the free evolution error is greater than 0.043, Grover algorithm does not work for any number of qubits affected by the present error model. The improvement in the probability of success, in the case of two qubits has been illustrated by using a fault-tolerant encoding of the initial state by means of the [[7,1,3]] quantum code.Comment: Accepted to be published in Eur. Phys. J. D (2008

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.

Killer-cell immunoglobulin-like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host immune responses, both innate and adaptive, through their expression by natural killer cells and T cells. Second, KIR play a key role in regulating placentation, and hence reproductive success. Analogous to the diversity of their human leucocyte antigen class I ligands, KIR are extremely polymorphic. In this review, we describe recent developments, fuelled by methodological advances, that are helping to decipher the KIR system in terms of haplotypes, polymorphisms, expression patterns and their ligand interactions. These developments are delivering deeper insight into the relevance of KIR in immune system function, evolution and disease.V.B. is supported by the French National Research Agency (ANR) (grant no. NKIR-ANR-13-PDOC-0025-01). P.J.N. and H.H. are supported by U.S. National Institutes of Health grant R01 AI17892. J.A.T. is supported by the European Research Council (ERC) and Medical Research Council (MRC)